CORE
πΊπ¦Β
Β make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
unknown
Invasive bacterial co-infection in African children with Plasmodium falciparum malaria: a systematic review.
Authors
A Farnert
A Honnas
+68Β more
AJ Brent
AJ Brent
AJ Cunnington
AL Walsh
AM Dondorp
AM Dondorp
B Blomberg
B Nadjm
B Sigauque
B Sigauque
CA Moxon
CJ Uneke
D Wolday
DC Mabey
E Pongponratn
EA Reddy
FN Okwara
G Enwere
G Enwere
G Giglioli
G Mackenzie
G Mtove
G Mtove
GO Akpede
H Lode
IA Angyo
J Berkley
J Prada
JA Berkley
JA Berkley
JA Berkley
JA Berkley
JA Evans
JA Scott
James Church
JL Neyeloff
JS Cheesbrough
K Maitland
K Maitland
K Thriemer
Kathryn Maitland
KB Seydel
KE Anderson
KO Akinyemi
L Manning
M English
MB Duggan
OO Ayoola
P Bahwere
P Lepage
P Olupot-Olupot
P Wilairatana
PG Kremsner
PO Okunola
Q Bassat
R Tripathy
RA Olsson
RN Bronzan
SM Graham
SM Graham
SS Pattanaik
ST Agnandji
T Were
TJ O'Dempsey
V Mulenga
World Health Organization
World Health Organization
World Health Organization
Publication date
1 January 2014
Publisher
'Springer Science and Business Media LLC'
Doi
Cite
View
on
PubMed
Abstract
Background: Severe malaria remains a major cause of pediatric hospital admission across Africa. Invasive bacterial infection (IBI) is a recognized complication of Plasmodium falciparum malaria, resulting in a substantially worse outcome. Whether a biological relationship exists between malaria infection and IBI susceptibility remains unclear. We, therefore, examined the extent, nature and evidence of this association.Methods: We conducted a systematic search in August 2012 of three major scientific databases, PubMed, Embase and Africa Wide Information, for articles describing bacterial infection among children with P. falciparum malaria using the search string (malaria OR plasmodium) AND (bacteria OR bacterial OR bacteremia OR bacteraemia OR sepsis OR septicaemia OR septicemia). Eligiblity criteria also included studies of children hospitalized with malaria or outpatient attendances in sub-Saharan Africa.Results: A total of 25 studies across 11 African countries fulfilled our criteria. They comprised twenty cohort analyses, two randomized controlled trials and three prospective epidemiological studies. In the meta-analysis of 7,208 children with severe malaria the mean prevalence of IBI was 6.4% (95% confidence interval (CI) 5.81 to 6.98%). In a further meta-analysis of 20,889 children hospitalised with all-severity malaria and 27,641 children with non-malarial febrile illness the mean prevalence of IBI was 5.58 (95% CI 5.5 to 5.66%) in children with malaria and 7.77% (95% CI 7.72 to 7.83%) in non-malaria illness. Ten studies reported mortality stratified by IBI. Case fatality was higher at 81 of 336, 24.1% (95% CI 18.9 to 29.4) in children with malaria/IBI co-infection compared to 585 of 5,760, 10.2% (95% CI 9.3 to 10.98) with malaria alone. Enteric gram-negative organisms were over-represented in malaria cases, non-typhoidal Salmonellae being the most commonest isolate. There was weak evidence indicating IBI was more common in the severe anemia manifestation of severe malaria.Conclusions: The accumulated evidence suggests that children with recent or acute malaria are at risk of bacterial infection, which results in an increased risk of mortality. Characterising the exact nature of this association is challenging due to the paucity of appropriate severity-matched controls and the heterogeneous data. Further research to define those at greatest risk is necessary to target antimicrobial treatment. Β© 2014 Church and Maitland; licensee BioMed Central Ltd
Similar works
Full text
Open in the Core reader
Download PDF
Available Versions
Springer - Publisher Connector
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 05/06/2019
Supporting member
Spiral - Imperial College Digital Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:spiral.imperial.ac.uk:1004...
Last time updated on 01/06/2014
Springer - Publisher Connector
See this paper in CORE
Go to the repository landing page
Download from data provider
Last time updated on 03/05/2017
Digital Library of the Tanzania Health Community
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:ihi.eprints.org:2519
Last time updated on 05/03/2014
Crossref
See this paper in CORE
Go to the repository landing page
Download from data provider
info:doi/10.1186%2F1741-7015-1...
Last time updated on 04/12/2019