Metabolism – A cornerstone of cancer initiation, progression, immune evasion and treatment response

Abstract

Cancer is not a single disease, but a spectrum of diseases with common hallmarks. One of these hallmarks is deregulated metabolism. Changes in the metabolism of cancers are not a mere downstream event of an oncogenic transformation; rather, metabolism is an essential cornerstone enabling various aspects of cancer. In this review, we highlight the role of metabolism in cancer initiation, proliferation, metastasis formation, immune evasion, and therapy response. We further provide metabolic concepts by which metabolic pathways support these different aspects of cancer.status: publishe