Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition

Abstract

In Alzheimer's disease (AD), pathologic amyloid-beta (Aβ) is synaptotoxic and impairs neuronal function at the microscale, influencing brain networks at the macroscale before Aβ deposition. The latter can be detected noninvasively, in vivo, using resting-state functional MRI (rsfMRI), a technique used to assess brain functional connectivity (FC).publisher: Elsevier articletitle: Early pathologic amyloid induces hypersynchrony of BOLD resting-state networks in transgenic mice and provides an early therapeutic window before amyloid plaque deposition journaltitle: Alzheimer's & Dementia articlelink: http://dx.doi.org/10.1016/j.jalz.2016.03.010 content_type: article copyright: © 2016 The Alzheimer's Association. Published by Elsevier Inc. All rights reserved.status: publishe