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Role of genetic factors in pathophysiology of multiple sclerosis
Authors
Bénédicte Dubois
An Goris
Kelly Hilven
Publication date
1 January 2015
Publisher
'Elsevier BV'
Doi
Cite
Abstract
© 2016 Elsevier Inc. All rights reserved. Epidemiological studies have pointed to an important role of genetics in the susceptibility to multiple sclerosis. Large-scale collaborations have led to an enormous expansion of known susceptibility variants with a current list of more than 100 established risk loci. In this chapter, we review the identification of these risk variants and explore possible sources of additional genetic variation. Furthermore, we demonstrate the influence of these and additional genetic risk variants on disease phenotype and pathogenesis. © 2016 Copyrightedition: 1ststatus: publishe
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Last time updated on 10/12/2019