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In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects
Authors
Bertil Abrahamsson
Patrick Augustijns
+25 more
Dieter Becker
Michael B Bolger
Marcus Brewster
Joachim Brouwers
Talia Flanagan
Matthew Harwood
Christian Heinen
Rene Holm
Hans-Paul Juretschke
Marlies Kubbinga
Peter Langguth
Hans Lennernäs
Anders Lindahl
Viera Lukacova
Uwe Münster
Sibylle Neuhoff
Mai Anh Nguyen
Christos Reppas
Amin Rostami
Erik Sjögren
Christer Tannergren
Achiel van Peer
Werner Weitschies
Clive Wilson
Patricia Zane
Publication date
21 February 2014
Publisher
'Elsevier BV'
Doi
Cite
Abstract
This review summarizes the current knowledge on anatomy and physiology of the human gastrointestinal tract in comparison with that of common laboratory animals (dog, pig, rat and mouse) with emphasis on in vivo methods for testing and prediction of oral dosage form performance. A wide range of factors and methods are considered in addition, such as imaging methods, perfusion models, models for predicting segmental/regional absorption, in vitro in vivo correlations as well as models to investigate the effects of excipients and the role of food on drug absorption. One goal of the authors was to clearly identify the gaps in today's knowledge in order to stimulate further work on refining the existing in vivo models and demonstrate their usefulness in drug formulation and product performance testing.publisher: Elsevier articletitle: In vivo methods for drug absorption – Comparative physiologies, model selection, correlations with in vitro methods (IVIVC), and applications for formulation/API/excipient characterization including food effects journaltitle: European Journal of Pharmaceutical Sciences articlelink: http://dx.doi.org/10.1016/j.ejps.2014.02.010 content_type: article copyright: Copyright © 2014 Elsevier B.V. All rights reserved.status: publishe
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Last time updated on 10/12/2019