Development of a new model for the study of Tauopathies

Abstract

Two of the main hallmarks in many neurodegenerative diseases called tauopathies are hyperfosforylation and aggregation of protein Tau. A lot of research on the processes involved in tau biology has been done in a well known yeast model for the study of Tau biology, namely the Saccharomyces cerevisiae model. In order to study toxicity of Tau in yeast cells in parallel with the hyperfosforylation and aggregation, we have developed a new Schizosaccharomyces pombe yeast model. On this poster we show some crucial results that were obtained in this human tau-expressing yeast model that can pinpoint the potential of this model for future studies for the modulators of Tau toxicity and the cellular processes involved in Tau biology.status: publishe