CMOS APS in pre-clinical science: next generation disruptive technology for multi-modality imaging

Abstract

A new large area CMOS Active Pixel Sensor has been developed as single platform technology to be used across a range of ionizing and non-ionizing imaging applications in preclinical science, ranging from imaging of protein sequences to functional analysis of radio-labeled tissue sections.We present the first images of chemiluminescence detection in western blotting with a room temperature CMOS APS. Detection performance in western blotting have been compared with the gold standard detection medium, film emulsion, showing higher dynamic range and sensitivity with this new device. We also report on our first images of 125IEpibatidine autoradiography of brain sections using a novel large area CMOS APS. © 2012 IEEE