In vivo chemistry for pretargeted tumor imaging in live mice

Abstract

\u3cp\u3eFigure Presented Mice and men: An antibody conjugate with trans-cyclooctene was administered to tumor-bearing mice, and the resulting chemically tagged tumors were subsequently treated with an \u3csup\u3e111\u3c/sup\u3eIn-labeled tetrazine probe in an inverse-electrondemand Diels-Alder reaction. The adduct was formed in a remarkable 52-57% yield in vivo and used for non-invasive pretargeted tumor imaging in mice (see pietu re).\u3c/p\u3