Recent Trends in Sterilization Methods of Biopolymer Biomaterials

Abstract

Sterilization problems of various biopolymers used as biomaterials are still continuing today. Since biopolymers are not resistant to such effects as high temperature, pressure, strain, etc., the existing methods are still being used for sterilization while new quests are ongoing. Due to the different properties of each of the various biopolymers, it is necessary to investigate and apply the different and optimal solution method for each. Chitosan, Polylactic Acid (PLA), Poly Lactic Glyco Acid (PLGA) used as cell skeleton in tissue engineering, silk fibrin used for cell skeleton, bioadhesive plasma and Ultra High Molecular Weight Polyethylene (UHMWPE), there is a need for separate sterilization for each of the different types and properties of biopolymers. Sterilization methods such as Gamma/Beta/UV irradiation, ethylene oxide, water vapor, plasma (RFGD), CO2,&nbsp;Peracetic acid / antibiotic solution, autoclave, dry heat is still used. However, if these methods are not suitable for the material, the chemical and physical structure of the biopolymer used may be impaired and the plasma properties and density may change. It has been observed that various methods must be used for the sterilization of various polymers in different physical states on the basis of the studies made. Despite the fact that the most common method used in the world is the gamma irradiation method, the negative effects of gamma rays on the environment, the user and the material are known and new investigations continue. In the target sterilization method, the material is intended to&nbsp;remain sterile and to remain unchanged without deteriorating its original properties. For all these reasons, a search for newer sterilization methods is still needed.KEYWORDS - Biopolymer Sterilization, Sterilization Problems, Biopoly</p