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尺寸均一的壳聚糖微球的制备及其作为胰岛素控释载体的研究
Authors
古永红
王连艳
谭天伟
马光辉
Publication date
1 January 2006
Publisher
Abstract
采用新型微孔膜乳化技术制备了栽胰岛素的壳聚糖微球。研究表明,要制备粒径均一的壳聚糖微球,必须将亲水性膜修饰成疏水性;制得的微球粒径和所采用的膜孔径之间存在很好的线性关系,使得微球粒径可控;以胰岛素为模型药物,主要考察了交联荆用量和交联时间对微球表面形态、药物包埋率和微球体外释药特性的影响。结果表明当氨基与醛基的摩尔比为1:0.7、交联时间为1h时,所得栽药微球的包埋率最高,随着戊二醛用量的增加和交联时间的延长,药物体外释放速率减慢
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Last time updated on 05/12/2019