CORE
🇺🇦
make metadata, not war
Services
Services overview
Explore all CORE services
Access to raw data
API
Dataset
FastSync
Content discovery
Recommender
Discovery
OAI identifiers
OAI Resolver
Managing content
Dashboard
Bespoke contracts
Consultancy services
Support us
Support us
Membership
Sponsorship
Community governance
Advisory Board
Board of supporters
Research network
About
About us
Our mission
Team
Blog
FAQs
Contact us
Insulin resistance in children with familial hyperlipidemia
Authors
Aoker M.
Bozdemir E.
+5 more
Habif S.
Kabaroglu C.
Kaylkçloglu M.
Terlemez S.
Uçar S.K.
Publication date
1 January 2018
Publisher
'Walter de Gruyter GmbH'
Doi
Cite
Abstract
PubMed ID: 30433876The aim of the study was to investigate whether there is insulin resistance in children with familial hyperlipidemia (FHL) and to determine the factors affecting insulin resistance. Hyperlipidemic children aged between 4 and 18 years and followed up with an FHL diagnosis were included in the study. The children of adults followed up with an FHL diagnosis were also recruited after the screening period. The scanned children were divided into two groups as hyperlipidemic and normolipidemic. A total of 77 patients of whom 52 were hyperlipidemic and 25 were normolipidemic were assessed in the study. Insulin resistance was evaluated (homeostatic model assessment of insulin resistance [HOMA-IR]) by performing the oral glucose tolerance test (OGTT). Of the patients, 36 were male and 41 were female; the average age was 11.6±3.9 years, and the body mass index (BMI) was established to be 20.3±4.4. In hyperlipidemic and normolipidemic patients, the following were determined: Fasting insulin: 10.6 (±0.89) µU/mL, 4.9 (±0.45) µU/mL (p=0.000); 2-h insulin: 28.7 (±12.7) µU/mL, 18.9 (±10.5) µU/mL (p=0.000); and HOMA-IR: 1.9 (±0.17), 0.86 (±0.7) (p=0.000). No relationship was identified between lipid profiles and insulin resistance. Nevertheless, there was a positive correlation between insulin resistance and apolipoprotein B (Apo B) levels (0.52), and a negative correlation was determined in carnitine levels (-0.64). Insulin resistance was established to be higher in children with FHL compared to normolipidemic children. Insulin resistance was not related to lipid phenotypes, but to Apo B levels and carnitine levels. Insulin resistance should be a routine method of evaluation in the follow-up of children with FHL. © 2018 Walter de Gruyter GmbH, Berlin/Boston
Similar works
Full text
Available Versions
Ege University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:gcris.ege.edu.tr:11454/250...
Last time updated on 23/11/2023