Recently, the relationship of nutrition/diet and pathogenesis of various diseases has been recognized. Investigators have made few studies on the nutrients that are essential for all fundamental cellular processess and their roles in modulating cellular oxidative damage and antioxidant defense. The aim of this investigation is to observe the antioxidant roles of vitamin E and selenium on CCl4-induced hepatotoxicity. Three groups of male Balbci mice were used in the experiments. The control group was fed a standard animal diet. The CCl4 group was treated with CC14 (1 mg/kg body weight) and the CCl4+ vitamin E group was given vitamin E (100 mg/kg) in addition to CCl4. After a period of 8 weeks determinations of selenium by atomic absorption spectrophotometry and vitmin E by HPLC were made in liver tissues of each three groups. A marked decrease in the values of selenium and vitamin E were noted in the group treated with CCl4. The results showed us that vitamin E had a protective effect on the hepatic cellular structure in CCl4 hepatotoxicity
