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In vitro anti-leishmanial activity of Sarcopoterium spinosum against Leishmania tropica [Sarcopoterium spinosum’un Leishmania tropica’ya karşı in vitro anti-leishmanial etkisi]
Authors
Bozkurt B.
Can H.
+4 more
Can Ş.
Döşkaya M.
Kayalar H.
Töz S.
Publication date
1 January 2018
Publisher
'Ankara University'
Doi
Cite
Abstract
Complex clinical symptoms such as ulcerative skin lesions, destructive mucosal inflammation, and disseminated visceral infection can reveal in leishmaniasis. The conventional drugs are toxic and expensive. In addition, patients receive a long treatment with these drugs which have adverse effects and unfortunately there are some limitations during the treatment. The aim of this study is to investigate the in vitro anti-leishmanial activities of four different extracts of Sarcopoterium spinosum against Leishmania tropica. Initially, different concentrations of ethanol, methanol, n-hexane, and water extracts of S. spinosum were incubated with L. tropica promastigotes. After 72 hours of incubation, the growth of L. tropica promastigotes was significantly inhibited and the percentage of inhibition ranged between 42.8 and 100 %. Among these extracts, the most efficient growth inhibition (100 %) was obtained with methanol extract (at a dose of 50 µg/ml). In conclusion, S. spinosum may be a potential source for the development of novel therapeutic agents to treat L. tropica infection. © 2018, Chartered Inst. of Building Services Engineers. All rights reserved
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Ege University Institutional Repository
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oai:gcris.ege.edu.tr:11454/252...
Last time updated on 23/11/2023
Ege University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:gcris.ege.edu.tr:11454/309...
Last time updated on 23/11/2023
Ege University Institutional Repository
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:gcris.ege.edu.tr:11454/661...
Last time updated on 23/11/2023