Demirtas, Yasemin

Emre, Memet Hanifi

Karaoglan, Mehmet

Sahin, Idris

Taskapan, Hulya

Acta Physiologica

WOS: 000379514000214Aim: Cognitive decline is an important problem for individuals, as well as for the community. Increasing evidence suggests that vitamin D may play a role in maintaining cognitive function and vitamin D deficiency may accelerate cognitive decline. The aim of this study was to evaluate the status of vitamin D in chronic renal failure (CRF) patients on peritoneal dialysis (PD) and to correlate the findings with cognitive functions. Materials and methods: The study was performed in Inonu University Turgut Ozal Medical Center. Serum 25hydroxyvitamin D (25(OH)D) was measured and cognitive functions (Wechsler Adult Intelligence Scale’s (WAIS) Comprehension Subtest) tested with 51 peritoneal dialysis patients and a control group consisting of 51 healthy individuals have similar conditions with patients. Individuals with other chronic diseases and smoking and alcohol habits which may impair cognitive functions were excluded from the study. Results: Compared to each groups we found negative correlation between 25(OH)D3 levels and WAIS’s Comprehension Subtest in patient and control group. The correlation between data was evaluated with the Spearman’s test (P = 0.597, r = 0.76 and P = 0.010 r = 0.356 respectively). Conclusions: In the literature, there is no consensus on the presence of an association between vitamin D levels and cognition. In this study vitamin D levels were measured as deficiency in both groups. Further studies are needed to investigate for increasing actual knowledge about this association

Karaoğlan, Mehmet

Demirtaş, Yasemin

Şahin, İdris

Taşkapan, Hülya

Mardin Artuklu University Institutional Repository

PO.152Correlation between vitamin D statusand Wechsler Adult IntelligenceScale’s comprehension subtest inpatient with end-stage renal diseasesMehmet Karaoglan1, Memet Hanifi Emre2,Yasemin Demirtas3, Idris Sahin4, Hulya Taskapan41Department of Nursing, School of Health, Mardin ArtukluUniversity, Mardin, Turkey; 2Department of Physiology,Faculty of Medicine, Inonu University, Malatya, Turkey;3Department of Neurology, Faculty of Medicine, InonuUniversity, Malatya, Turkey; 4Nephrology Division,Department of Internal Medicine, Faculty of Medicine,Inonu University, Malatya, TurkeyAim: Cognitive decline is an important problem forindividuals, as well as for the community. Increasingevidence suggests that vitamin D may play a role inmaintaining cognitive function and vitamin D deficiencymay accelerate cognitive decline. The aim of this studywas to evaluate the status of vitamin D in chronic renalfailure (CRF) patients on peritoneal dialysis (PD) and tocorrelate the findings with cognitive functions.Materials and methods: The study was performed inInonu University Turgut Ozal Medical Center. Serum25hydroxyvitamin D (25(OH)D) was measured andcognitive functions (Wechsler Adult Intelligence Scale’s(WAIS) Comprehension Subtest) tested with 51 peri-toneal dialysis patients and a control group consistingof 51 healthy individuals have similar conditions withpatients. Individuals with other chronic diseases andsmoking and alcohol habits which may impair cognitivefunctions were excluded from the study.Results: Compared to each groups we found negativecorrelation between 25(OH)D3 levels and WAIS’sComprehension Subtest in patient and control group.The correlation between data was evaluated with theSpearman’s test (P = 0.597, r = 0.76 and P = 0.010r = 0.356 respectively).Conclusions: In the literature, there is no consensuson the presence of an association between vitamin Dlevels and cognition. In this study vitamin D levelswere measured as deficiency in both groups. Furtherstudies are needed to investigate for increasing actualknowledge about this association.PO.153Modulation of spatiotemporalcalcium dynamics in single astrocytesby neuronal activityYulia Dembitskaya, Alexey SemyanovNeuroscience Center, Lobachevsky State University ofNizhny Novgorod, Nizhny Novgorod, RussiaAstrocytes play a number of important functions inthe brain trough a generation of a repertoire ofcomplex Ca2+ events. Although the astrocytic Ca2+signalling has been intensively studied for a severallast decades the principle of Ca2+ events integration inastrocytes during synaptic activity, however, remainsunknown. Here we implemented an analysis of wholeCa2+ events (Wu et al., 2014 in single astrocytes inmice hippocampal slices and we found that spreadsand durations of Ca2+ events follow power law distri-butions, a fingerprint of scale-free systems. The powerlaw exponent (a) was decreased by activation of meta-botropic glutamate receptors (mGluRs) either byspecific receptor agonist, glutamate uncaging aroundastrocytic processes or by low frequency stimulationof glutamatergic fibers in hippocampal slices. Decreasein a indicated an increase in proportion of large Ca2+events. Notably, mGluRs activation did not increasethe frequency of whole Ca2+ events. This result sug-gests that neuronal activity does not trigger new Ca2+events in astrocytes (detectable by our methods), butmodulates the properties of existing ones. Pharmaco-logical blockade of mGluRI leads to the decrease ofthe proportion of large Ca2+ events, suggesting thatsuch Ca2+ dynamics might arise from intracellularinositol-3-phosphate diffusion triggered by mGluRsactivation during synaptic transmission. Thus, ourresults provide a new perspective on how astrocyteresponds to neuronal activity by changing its Ca2+dynamics, which might further affect synaptic trans-mission and local network functioning.PO.154Effect of specific energy substrates onastrocytes calcium dynamic in the rathippocampusAlbina Lebedeva, Elena Shishkova, AlexeySemyanovLobachevsky State University of Nizhny Novgorod, NizhnyNovgorod, RussiaRecent studies have demonstrated the important roleof astrocytes in memory formation through delivery oflactate to neurons. During neuronal activity and incertain pathologies, the synthesis of lactate is activatedin astrocytes. Because neuronal activity depends onenergy substrate accessibility, this process serves as aregulatory mechanism for some neuronal functions.Lactate and pyruvate also become the main energysubstrates in the brain when the glucose level is low.In addition, ketone bodies can serve as energy sub-strate in the neonatal brain. Using laser confocalmicroscopy we investigated how lactate, pyruvate andbeta-desoxybutirate, thereafter specific energy sub-strates (SES), affect calcium dynamics in astrocytes inrat hippocampal slices at different stages of postnatalbrain development: postnatal day (P) 5, 15 and 30.The astrocytes were stained with Oregon GreenBAPTA AM (7.95 lM) and specific astrocytic markerActa Physiol 2016, 217 (Suppl. 708), 3–158© 2016 The Authors. Acta Physiologica © 2016 Scandinavian Physiological Society. Published by John Wiley & Sons Ltd94Abstracts

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Correlation between vitamin D status and Wechsler Adult Intelligence Scale's comprehension subtest in patient with end-stage renal diseases

Correlation between vitamin D status and Wechsler Adult Intelligence Scale's comprehension subtest in patient with end-stage renal diseases

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