Not AvailableFresh head waste of sardine, threadfin bream, anchovy and tilapia was converted into fish meal after cooking and pressing. Whole sardine was used as control sample. Quality analysis of the prepared meal revealed that the protein content was lower for sardine waste (43.1 percentage) and higher for tilapia (62.3 percentage) The fish meal prepared was used as the protein source for preparing feed along with other ingredients. Isoprotenous feed prepared was administered in Wistar strain male albino rats for a period of 31 days and Feed Intake (FI) Protein Efficiency Ratio (PER) and Feed Conversion Ratio (FCR) was estimated. Feed intake was more in threadfin bream waste feed and anchovy waste feed (135.1 grams per 31 days) which was significantly different from other feeds. The acceptance of feed developed from the waste of fish shows more or less similar to control feed indicating that the waste can be utilized for the development of feed for different animals thereby resolving the problem of environmental pollution.Not Availabl