Arden, Nigel

Beard, David

Campbell, Helen

Campbell, Marion

Carr, Andrew

Cook, Jonathan

Cooper, Cushla

Davies, Loretta

Doll, Helen

Fitzpatrick, Ray

Murray, David

Price, Andrew

Trials

English

PubMed

David Beard

Andrew Price

Jonathan Cook

Ray Fitzpatrick

Andrew Carr

Marion Campbell

Helen Doll

Helen Campbell

Nigel Arden

Cushla Cooper

Loretta Davies

David Murray

Springer - Publisher Connector

Total or Partial Knee Arthroplasty Trial - TOPKAT: study protocol for a randomised controlled trial

Crossref

BACKGROUND: In the majority of patients with osteoarthritis of the knee the disease originates in the medial compartment. There are two fundamentally different approaches to knee replacement for patients with unicompartmental disease: some surgeons feel that it is always best to replace both the knee compartments with a total knee replacement (TKR); whereas others feel it is best to replace just the damaged component of the knee using a partial or unicompartment replacement (UKR). Both interventions are established and well-documented procedures. Little evidence exists to prove the clinical and cost-effectiveness of either management option. This provides an explanation for the high variation in treatment of choice by individual surgeons for the same knee pathology.The aim of the TOPKAT study will be to assess the clinical and cost effectiveness of TKRs compared to UKRs in patients with medial compartment osteoarthritis. METHODS/DESIGN: The design of the study is a single layer multicentre superiority type randomised controlled trial of unilateral knee replacement patients. Blinding will not be possible as the surgical scars for each procedure differ.We aim to recruit 500 patients from approximately 28 secondary care orthopaedic units from across the UK including district general and teaching hospitals. Participants will be randomised to either UKR or TKR. Randomisation will occur using a web-based randomisation system. The study is pragmatic in terms of implant selection for the knee replacement operation. Participants will be followed up for 5 years. The primary outcome is the Oxford Knee Score, which will be collected via questionnaires at 2 months, 1 year and then annually to 5 years. Secondary outcomes will include cost-effectiveness, patient satisfaction and complications data. TRIAL REGISTRATION: Current Controlled Trials ISRCTN03013488; ClinicalTrials.gov Identifier: NCT01352247

Fitzpatrick, R

Campbell, M

Doll, H

Cooper, Cyrus

Davies, L

ORA - Oxford University Research Archive

Total or Partial Knee Arthroplasty Trial - TOPKAT: study protocol for a randomised controlled trial.

Beard, D

Price, A

Cook, J

Carr, A

Campbell, H

Arden, N

Cooper, C

Murray, D

Oxford University Research Archive (ORA)

Oxford University Research Archive

Aberdeen University Research

A: Questionnaire on the perceptions of patients about total knee replacement.

Accuracy of implantation of a unicompartmental total knee arthroplasty with 2 different instrumentations: a case-controlled comparative study.

Ackroyd CE: The length of the patellar tendon after unicompartmental and total knee replacement. J Bone Joint Surg Br

AJ: Decision making For knee replacement: variation In treatment choice for late stage medial compartment osteoarthritis. Knee

AJ: Minimal important change or difference for the Oxford Hip and Knee scores following joint replacement surgery. Toronto: ISAKOS conference proceedings;

BiermaZeinstra SMA: Braces and orthoses for treating osteoarthritis of the knee. Cochrane Database Syst Rev

Brenkel IJ: Unicompartmental or total knee arthroplasty?: Results from a matched study. Clin Orthop Relat Res

CK: Polyethylene wear of metal-backed tibial components in total and unicompartmental knee prostheses.

Della Valle CJ: Total knee arthroplasty has higher postoperative morbidity than unicompartmental knee arthroplasty: a multicenter analysis.

DW: Does arthroplasty type influence knee joint proprioception? A longitudinal prospective study comparing total and unicompartmental arthroplasty. Knee

DW: Rapid recovery after oxford unicompartmental arthroplasty through a short incision.

EuroQol: the current state of play. Health Policy

Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev

FC: Unicompartmental versus total knee arthroplasty in the same patient. A comparative study. Clin Orthop Relat Res

GA: Viscosupplementation for the treatment of osteoarthritis of the knee. Cochrane Database Syst Rev

Haas B: In vivo three-dimensional determination of kinematics for subjects with a normal knee or a unicompartmental or total knee replacement.

HC: Assessing activity in joint replacement patients.

Implant position in knee surgery: a comparison of minimally invasive, open unicompartmental, and total knee arthroplasty.

JH: Radiological changes five years after unicompartmental knee replacement.

Jung YB: A comparison of unicompartmental knee replacement with total knee replacement. Orthop Rev

JW: Anteromedial osteoarthritis of the knee.

KAT Trial Group: Patellar resurfacing in total knee replacement: five-year clinical and economic results of a large randomized controlled trial. J Bone Joint Surg Am

KAT Trial Group: The Knee Arthroplasty Trial (KAT) design features, baseline characteristics, and two-year functional outcomes after alternative approaches to knee replacement.

KJ: Outcomes of total and unicompartmental knee arthroplasty for secondary and spontaneous osteonecrosis of the knee.

Lidgren L: Patient satisfaction after knee arthroplasty: a report on 27,372 knees operated on between 1981 and 1995 in Sweden. Acta Orthop Scand

Observed kneeling ability after total, unicompartmental and patellofemoral knee arthroplasty: perception versus reality. Knee Surg Sports Traumatol Arthrosc

Osteotomy for treating knee osteoarthritis. Cochrane Database Syst Rev

Park YS: Total knee replacement following high tibial osteotomy and unicompartmental knee. Orthopedics

PJ: Deehan: Comparison of patient reportd outcome measures following total and unicondylar knee replacement. J Bone Joint Surg Br

Revision of Oxford medial unicompartmental knee arthroplasty to total knee arthroplasty -results of a multicentre study. Knee

Revision rates after total joint replacement. Cumulaive results from worldwide joint register datasets.

Revision total knee arthroplasty for failed unicompartmental replacement.

Revision total knee arthroplasty. Comparison of outcome following primary proximal tibial osteotomy or unicompartmental arthroplasty.

Survival and functional outcome after revision of a unicompartmental to a total knee replacement: the New Zealand National Joint Registry. J Bone Joint Surg Br

The survivorship and results of total knee replacements converted from unicompartmental knee replacements. Knee

The use of the Oxford hip and knee score. J Bone Joint Surg Br

Thornhill TS: Conversion of failed modern unicompartmental arthroplasty to total knee arthroplasty.

Thornhill TS: Revision total knee arthroplasty after failed unicompartmental knee arthroplasty or high tibial osteotomy. Clin Orthop Relat Res

Tibshirani R: Bootstrap methods for standard errors, confidence intervals, and other measures of statistical accuracy. Stat Sci

Tosteson A: Cost-effectiveness of unicompartmental and total knee arthroplasty in elderly low-demand patients. A Markov decision analysis.

Unicompartmental or total knee replacement? Five-year results of a prospective, randomised trial of 102 osteoarthritic knees with unicompartmental arthritis.

Unicompartmental or total knee replacement. The 15-year results of a prospective randomised controlled trial. J Bone Joint Surg Br

Unicompartmental versus computerassisted total knee replacement for medial compartment knee arthritis: a matched paired study. Int Orthop

Unicondylar knee arthroplasty in the UK National Health Service: an analysis of candidacy, outcome and cost efficacy. Knee

Use of a new high-activity Arthroplasty score to assess function of young patients with total hip or knee Arthroplasty.

Weale AE: Radiological changes ten years after St. Georg Sled unicompartmental knee replacement. Knee

WN: Rationale of the Knee Society clinical rating system. Clin Orthop Relat Res

Total or Partial Knee Arthroplasty Trial - TOPKAT : study protocol for a randomised controlled trial

https://aura.abdn.ac.uk/bitstream/2164/3094/1/Beard_2013.pdf

Total or Partial Knee Arthroplasty Trial - TOPKAT : study protocol for a randomised controlled trial

Abstract

Similar works

Full text

Available Versions

Springer - Publisher Connector

Crossref

ORA - Oxford University Research Archive

Oxford University Research Archive (ORA)

Oxford University Research Archive

Springer - Publisher Connector

Aberdeen University Research