Vulvovaginal Candidiasis (VVC) has varied etiology. The yeasts involved in the disease have been presenting increased resistance to the azoles and poliens, the drugs of choice for treatment. In recurrent VVC, the therapeutic difficulties are even greater. The epidemiological relevance of etiological diagnosis and antifungigram in clinical treatment is discussed. Vulvovaginal candidiasis (VVC) has a varied aetiology. The yeasts involved in this disease have presented increased resistance to the azoles and poliens, the drugs of choice for treatment. In recurrent VVC, the therapeutic difficulties are even greater. The epidemiological relevance of aetiological diagnosis and of the antifungigram in clinical treatment is discussed