Meiotic drive is the phenomenon in which an allele or piece of chromosome occurs in > 50% of the progeny of heterozygous parents, a result contrary to Mendel's law of segregation. An example of meiotic drive that occurs in the fruit fly Drosophila melanogaster is the Segregation Distortion system (SD). In the SD system, the allele Segregation Distorter (Sd) eliminates spermatids carrying the allele Responder (Rsp). Rsp bearing spermatids fail to undergo chromatin condensation and subsequently fail to separate properly
