A. Gorusupudi

B. Li

B. M. Besch

BEATTY

Bhatti

Bone

Connor

Cunningham Jr

Desvergne

Eriksson

Fierce

Garci  a-Limones

H. Sharifzadeh

J. M. Frederick

K. Nelson

Khachik

Kiefer

Kloer

Krinsky

Landrum

Loane

M. M. Horvath

Mein

P. P. Vachali

P. S. Bernstein

Rich

Tian

Vachali

Vage

W. Baehr

Whitehead

Z. Shen

Significance
          
            Among mammals, only primates can accumulate high levels of xanthophyll carotenoids in their retinas. We discovered that, unlike most other mammals, the major xanthophyll cleavage enzyme β,β-carotene-9′,10′-dioxygenase (BCO2) is inactive in humans, explaining the unique accumulation of lutein, zeaxanthin, and
            meso
            -zeaxanthin in primate macula. We confirmed this discovery by demonstrating that BCO2 knockout mice accumulate zeaxanthin in their retinas.
          </jats:p

Binxing Li

Preejith P. Vachali

Aruna Gorusupudi

Zhengqing Shen

Hassan Sharifzadeh

Brian M. Besch

Kelly Nelson

Madeleine M. Horvath

Jeanne M. Frederick

Wolfgang Baehr

Paul S. Bernstein

Crossref

Proceedings of the National Academy of Sciences

Inactivity of human β,β-carotene-9′,10′-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment

Inactivity of human  , -carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment

Inactivity of human , -carotene-9',10'-dioxygenase (BCO2) underlies retinal accumulation of the human macular carotenoid pigment

Abstract

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