Annich G

Barstad RM

Bolton FJ

Butt E

Cunningham MT

Dalabih A

Ebert RF

Eigenthaler M

Gail M Annich

Handa HB

Hitesh Handa

Huang S

Kanade S

Kosasih H

Lamarche Y

Lane DA

Lindhout T

Martens S

Meinhardt JP

Newland RF

Nsagha DS

Ottens J

Preston TJ

Ranucci M

Riesenfeld J

Robert H Bartlett

Seeburger J

Silpasakorn S

Stammers AH

Terry C Major

Tevaearai HT

Toda R

van der Kamp KW

Vaughn MW

Vienken J

Yoshizaki T

 Hemocompatibility is the goal for any biomaterial contained in extracorporeal life supporting medical devices. The hallmarks for hemocompatibility include nonthrombogenicity, platelet preservation, and maintained platelet function. Both in vitro and in vivo assays testing for compatibility of the blood/biomaterial interface have been used over the last several decades to ascertain if the biomaterial used in medical tubing and devices will require systemic anticoagulation for viability. Over the last 50 years systemic anticoagulation with heparin has been the gold standard in maintaining effective extracorporeal life supporting. However, the biomaterial that maintains effective ECLS without the use of any systemic anticoagulant has remained elusive. In this review, the in vivo 4-h rabbit thrombogenicity model genesis will be described with emphasis on biomaterials that may require no systemic anticoagulation for extracorporeal life supporting longevity. These novel biomaterials may improve extracorporeal circulation hemocompatibility by preserving near resting physiology of the major blood components, the platelets and monocytes. The rabbit extracorporeal circulation model provides a complete assessment of biomaterial interactions with the intrinsic coagulation players, the circulating platelet and monocytes. This total picture of blood/biomaterial interaction suggests that this rabbit thrombogenicity model could provide a standardization for biomaterial hemocompatibility testing. </jats:p

Crossref

Journal of Biomaterials Applications

Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity

Development and hemocompatibility testing of nitric oxide releasing polymers using a rabbit model of thrombogenicity

Abstract

Similar works

Full text

Available Versions

Crossref