Coarse-Grained Analysis of Microscopic Neuronal Simulators on Networks: Bifurcation and Rare-events computations

Abstract

We show how the Equation-Free approach for mutliscale computations can be exploited to extract, in a computational strict and systematic way the emergent dynamical attributes, from detailed large-scale microscopic stochastic models, of neurons that interact on complex networks. In particular we show how the Equation-Free approach can be exploited to perform system-level tasks such as bifurcation, stability analysis and estimation of mean appearance times of rare events, bypassing the need for obtaining analytical approximations, providing an "on-demand" model reduction. Using the detailed simulator as a black-box timestepper, we compute the coarse-grained equilibrium bifurcation diagrams, examine the stability of the solution branches and perform a rare-events analysis with respect to certain characteristics of the underlying network topology such as the connectivity degre