A. Matsuda

Andersson

Calogero

Denes

Deretic

El Mezayen

Franchi

Gardella

H. Ikushima

H. Negishi

H. Ohdan

H. Yanai

Harris

J. An

J. Nishio

Kabeya

Kuida

Levine

Lotze

Maiuri

Martinon

N. Yoshida

Nakahira

Nystrom

Ogawa

R. Koshiba

Saitoh

Sakai

Sims

Sterner

Strowig

T. Onoe

T. Taniguchi

Tian

Wang

Yanai

Significance
          
            The high-mobility group box 1 (HMGB1) protein is abundantly expressed in the nucleus where it regulates chromatin function. More recently, it was found to also function in the cytoplasm and extracellular milieu for the regulation of immunity and inflammation. However, the in vivo study of HMGB1 has been hampered by the fact that HMGB1-deficient mice die soon after birth. In this study, we successfully generated
            Hmgb1
            -floxed mice to achieve conditional inactivation of the gene in a cell- and tissue-specific manner. We demonstrate that cytosolic HMGB1 in myeloid cells is critical for the protection of the host from endotoxemia and bacterial infection by inducing autophagy, a cellular response critical for maintaining cellular viability in the setting of various stresses including infection.
          </jats:p

Hideyuki Yanai

Atsushi Matsuda

Jianbo An

Ryuji Koshiba

Junko Nishio

Hideo Negishi

Hiroaki Ikushima

Takashi Onoe

Hideki Ohdan

Nobuaki Yoshida

Tadatsugu Taniguchi

Crossref

Proceedings of the National Academy of Sciences

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

Conditional ablation of HMGB1 in mice reveals its protective function against endotoxemia and bacterial infection

Abstract

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