AS Midgette

C Cho

C Gazquez

C Ravel

D Grassetti

DM de Kretser

DT Carrell

E Kichine

E Siasi

F Tuettelmann

GA Diamond

H Tanaka

J Poongothai

JP Higgins

KI Aston

KP Phillips

L Imken

M Egger

QF Yu

R Oliva

S Venkatesh

VW Aoki

W Wu

XF Zhang

XJ He

Y Seki

Y Yang

YY Shi

Z Zhang

Scientific Reports

AbstractSeveral studies have investigated the association between polymorphisms in protamine 1 and 2 genes and male infertility risk, with inconsistent results to date. This meta-analysis based on the 13 published case-control studies, including 7350 cases and 6167 controls, was performed to further establish the potential association between the 6 common single nucleotide polymorphisms (rs35576928, rs737008, rs35262993, rs2301365, rs1646022, rs2070923) in protamines 1 and 2 and male infertility. The -190C &gt; A (rs2301365) polymorphism was identified as a risk factor for male infertility under all models. Interestingly, rs1646022 and rs737008 polymorphisms exerted protective effects against male sterility in Asian and population-based under some models. No associations between the remaining SNPs and male sterility were observed.</jats:p

Weijun Jiang

Hui Sun

Jing Zhang

Qing Zhou

Qiuyue Wu

Tianfu Li

Cui Zhang

Weiwei Li

Mingchao Zhang

Xinyi Xia

Crossref

Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis

Polymorphisms in Protamine 1 and Protamine 2 predict the risk of male infertility: a meta-analysis

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