Antonio C. Bianco

Balázs Gereben

Barbara M. L. C. Bocco

Csaba Fekete

Daofeng Li

Elizabeth A. McAninch

Gustavo W. Fernandes

Miriam O. Ribeiro

Petra Mohácsik

Sherine M. Abdalla

Tatiana L. Fonseca

Ting Wang

Weisend

Xiaoyun Xing

Significance
          Thyroid hormone is secreted mostly as a prohormone that must be activated to gain biological activity. The activation reaction is the removal of one iodine atom, i.e., deiodination of thyroxine to active thyroid hormone triiodothyronine (T3), which is catalyzed by a group of enzymes known as deiodinases. These enzymes control the amounts of intracellular and circulating T3. Here we report that in mice, there is a brief neonatal surge in hepatocyte type 2 deiodinase (D2) that transiently stimulates liver expression of lipid-related genes. The surge in D2 also affects the pattern of DNA methylation and responsiveness of lipid-related genes, modifying metabolic susceptibility to liver steatosis, hypertriglyceridemia, and obesity.</jats:p

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Proceedings of the National Academy of Sciences

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity

Perinatal deiodinase 2 expression in hepatocytes defines epigenetic susceptibility to liver steatosis and obesity

Abstract

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