Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd-Chiari syndrome and portal vein thrombosis: results of a case-control study
In a collaborative multicenter case-control study, we investigated the
effect of factor V Leiden mutation, prothrombin gene mutation, and
inherited deficiencies of protein C, protein S, and antithrombin on the
risk of Budd-Chiari syndrome (BCS) and portal vein thrombosis (PVT). We
compared 43 BCS patients and 92 PVT patients with 474 population-based
controls. The relative risk of BCS was 11.3 (95% CI 4.8-26.5) for
individuals with factor V Leiden mutation, 2.1(95% CI 0.4-9.6) for those
with prothrombin gene mutation, and 6.8 (95% CI 1.9-24.4) for those with
protein C deficiency. The relative risk of PVT was 2.7 (95% CI 1.1-6.9)
for individuals with factor V Leiden mutation, 1.4 (95% CI 0.4-5.2) fo