research
Intracranial aneurysms and subarachnoid hemorrhage: Clinical studies on diagnosis and treatment
- Publication date
- 7 June 2006
- Publisher
- Computerized tomography angiography (CTA) can be
performed quicker, safer and cheaper than digital subtraction angiography
(DSA) in patients after aneurysmal subarachnoid hemorrhage (SAH). However,
DSA is still regarded as the gold standard in the diagnosis of
intracranial ruptured aneurysms. No studies have specifically addressed
the value of CTA in planning of endovascular treatment of ruptured
aneurysms. Mathieu van der Jagt investigates the diagnostic value of CTA
for endovascular treatment compared with DSA, in cooperation with
Radiology. He hypothesizes is that, at least in a subset of patients, CTA
suffices and DSA can be omitted in the planning of endovascular treatment.
Another project concerns a systematic review on rupture rate of unruptured
intracranial aneurysms (UIAs), estimating the rupture rate of UIAs based
on the available observational studies. The statistical method used will
allow for correction for methodological quality per study, lea!
ding to an estimate of rupture rate that is based on less biased data.
The PhD project also evaluates the localizing value of blood distribution
on CTA for the location of ruptured intracranial aneurysm; it includes a
cohort study on the impact of early surgery on overall outcome after
aneurysmal SAH.