Nielsen, Thomas Eiland

Qvortrup, Katrine

The present invention relates to a photolabile hydroxamate linker based on the o - nitroveratryl group and its application for multistep solid-phase synthesis and controlled photolytic release of hydroxamic acids. The invention provides a method for producing a solid support comprising a hydroxylamine - functionalized photolabile linker, and the so produced hydroxylamine - functionalized photolabile solid support. The invention further provides a method for synthesizing a one-bead-one compound library of hydroxamic acid derivatives on a photolabile linker, as well as a method for screening a library of hydroxamic acid derivatives

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Photolabile linker for the synthesis of hydroxamic acids

http://orbit.dtu.dk/ws/files/81304013/WO2013057186A1.pdf

Photolabile linker for the synthesis of hydroxamic acids

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