Aplastic anaemia is featured by bone marrow hypocellularity and peripheral
pancytopenia and is a potentially fatal disease. In recent years, insight
in it pathogenesis has increased. It appears that activated autoreactive T
lymphocytes induce apoptosis of haematopoietic stem cells resulting in a
hypocellular bone marrow. Nowadays, it can be treated by stem cell
transplantation or immunosuppressive therapy. This review focuses on the
pathophysiology and treatment of aplastic anaemia
