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Intronic features that determine the selection of the 3′ splice site
Authors
Abovich
Aitken
+101 more
Akerman
Barash
Berget
Berglund
Black
Bonnal
Cellini
Chang
Chang
Charpentier
Chasin
Chebli
Chen
Chiara
Collins
Cooper
Corioni
Corrionero
Corvelo
Crotti
de la Mata
Deshler
Egecioglu
Egecioglu
Elgar
Gahura
Gooding
Graveley
Guth
Guth
Hall
Hallegger
Han
Henscheid
Horowitz
Hoskins
Howe
Hsu
Hutton
Ip
Irimia
Izquierdo
Kennedy
Keren
Konarska
Konarska
Lacadie
Lallena
Lambowitz
Langford
Lev-Maor
Linder
Liu
Liu
Long
Luukkonen
López-Bigas
Mackereth
Mayas
Mayas
McManus
Meyer
Michael
Moore
Nilsen
Nilsen
Pandit
Patterson
Plass
Query
Raker
Reed
Reed
Roca
Roca
Ruby
Ruskin
Russell
Rutz
Rymond
Schwer
Seraphin
Sheth
Shukla
Smith
Smith
Soares
Spingola
Sridharan
Thompson-Jager
Umen
Urbanek
Wachter
Wang
Warf
Will
Will
Wu
Xu
Zhao
Zhuang
Publication date
29 November 2013
Publisher
'Wiley'
Doi
Cite
Abstract
Most eukaryotic primary transcripts include segments, or introns, that will be accurately removed during RNA biogenesis. This process, known as pre-messenger RNA splicing, is catalyzed by the spliceosome, accurately selecting a set of intronic marks from others apparently equivalent. This identification is critical, as incorrectly spliced RNAs can be toxic for the organism. One of these marks, the dinucleotide AG, signals the intronic 3′ end, or 3′ splice site (ss). In this review we will focus on those intronic features that have an impact on 3′ ss selection. These include the location and type of neighboring sequences, and their distance to the 3′ end. We will see that their interplay is needed to select the right intronic end, and that this can be modulated by additional intronic elements that contribute to alternative splicing, whereby diverse RNAs can be generated from identical precursors. This complexity, still poorly understood, is fundamental for the accuracy of gene expression. In addition, a clear knowledge of 3′ ss selection is needed to fully decipher the coding potential of genomes. © 2012 John Wiley & Sons, Ltd.Work in JV's laboratory is supported by the Spanish Ministry of Science (BIO2008-01091 and 2011-25697) and CSIC (200920I195).Peer Reviewe
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oai:digital.csic.es:10261/8792...
Last time updated on 25/05/2016
Crossref
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info:doi/10.1002%2Fwrna.1131
Last time updated on 03/12/2019