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research
Increased numbers of neurons occur in the inferior colliculus of the young genetically epilepsy-prone rat
Authors
HL Kim
CE Ribak
RC Roberts
Publication date
1 January 1985
Publisher
eScholarship, University of California
Abstract
To determine if the increase in the number of neurons observed in the inferior colliculus (IC) of the adult genetically epilepsy-prone rat (GEPR) as compared to the Sprague-Dawley rat was present in the young GEPRs prior to the time at which seizure activity commences, brains from both types of rats 4-10 days of age were studied. A statistically significant increase in the numbers of small neurons occurred in the IC of the young GEPR. At 4 days of age, a 55% increase in the number of small neurons was found in the GEPR as compared to the Sprague-Dawley rat and at 10 days of age this increase was 105%. The numbers of the medium and large neurons were similar in the older group of rats. These data suggest that the increase in cell number observed in the adult GEPR is not compensatory to the seizure activity, but is genetically programmed. © 1985
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Sustaining member
eScholarship - University of California
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oai:escholarship.org:ark:/1303...
Last time updated on 25/12/2021
Sustaining member
eScholarship - University of California
See this paper in CORE
Go to the repository landing page
Download from data provider
oai:escholarship.org:ark:/1303...
Last time updated on 25/12/2021