Glycosidase inhibition is expected to be addressed toward specific non-enantioselective, lipophilic enzymes, such as glucocerebrosidases GBA1 and GBA2. In order to assess the effect of chirality and lipophilicity of alkylated iminosugars on the activity/selectivity of such enzymes, some D and L-alkylated iminosugars as 1 and ent-1, in particular those having a gluco-configured pseudo-saccharide moiety (DNJ derivatives) have been synthesize
