Shamsi Meymandi, Reza

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   داﻧﺸﮕﺎه ﻋﻠﻮم ﭘﺰﺷﻜﻲ و ﺧﺪﻣﺎت ﺑﻬﺪاﺷﺘﻲ درﻣﺎﻧﻲ ﻛﺮﻣﺎن  داﻧﺸﻜﺪه داروﺳﺎزي و ﻋﻠﻮم داروﻳﻲ    ﻧﺎﻣﻪ دﻛﺘﺮاي ﻋﻤﻮﻣﻲ داروﺳﺎزي ﭘﺎﻳﺎن      ﻋﻨﻮان: اﺗﺎﻧﻮﻟﻲ ﻋﺼﺎره ﺟﻮﺷﺎن ﻗﺮص ﻓﻴﺰﻳﻜﻮﺷﻴﻤﻴﺎﻳﻲ ﺧﻮاص ﺑﺮرﺳﻲ و ﻓﺮﻣﻮﻻﺳﻴﻮن  )aeruprup aecanihcE( ﺳﺮﺧﺎرﮔﻞ ﮔﻴﺎه رﻳﺸﻪ ﺷﺪه اﺳﺘﺎﻧﺪارد      ﺗﻮﺳﻂ:  رﺿﺎ ﺷﻤﺴﻲ ﻣﻴﻤﻨﺪي      اﺳﺎﺗﻴﺪ راﻫﻨﻤﺎ:  ﭘﻴﺎم ﺧﺰاﺋﻠﻲدﻛﺘﺮ   ﻓﺮ ﻲﻔﻳﺷﺮدﻛﺘﺮ ﻓﺮﻳﺒﺎ         1311 ﻧﺎﻣﻪ: ﺷﻤﺎره ﭘﺎﻳﺎن                                                               8931 ﭘﺎﻳﻴﺰ  Kerman University of Medical Sciences Faculty of Pharmacy  Pharm. D Thesis     Title: Formulation and physicochemical evaluation of effervescent tablet containing standardized ethanolic extract of Moench root (Echinacea purpurea L.)    By: Reza Shamsi Meymandi    Supervisors: Dr. Payam Khazaeli Dr. Fariba Sharififar    Autumn 2019                                                 Thesis No: 1131      ﻓﺎرﺳﻲ ﺧﻼﺻﻪﻫـﺎ ﻣﺎﻧﻨـﺪ ﻤـﺎري اي از ﺑﻴﮔﺴـﺘﺮده ﺑـﺮاي ﭘﻴﺸـﮕﻴﺮي و درﻣـﺎن ﻃﻴـﻒ  در ﻃـﺐ ﺳـﻨﺘﻲ از ﮔﻴـﺎه ﺳـﺮﺧﺎرﮔﻞ  ﻣﻘﺪﻣﻪ:ﺎﺷـﻲ از ﻧﻘـﺺ اﻳﻤﻨـﻲ اﺳـﺘﻔﺎده ﻫـﺎي ﻣـﺰﻣﻦ ﻧ  ﻫﺎي رﻳﻮي و ﺣﺘﻲ ﺑﻴﻤﺎري ، ﺑﺮوﻧﺸﻴﺖ، ﻋﻔﻮﻧﺖ، ﺳﺮﻓﻪﺳﺮﻣﺎﺧﻮردﮔﻲﺟﻮﺷﺎن از ﺟﻤﻠﻪ ﭘﻮﺷﺎﻧﺪن ﻣﺰه ﻧﺎﻣﻄﻠﻮب، ﺣﻼﻟﻴـﺖ ﺑﻬﺘـﺮ و راﺣـﺖ ﺑـﻮدن ﺷﻮد. ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﻣﺰاﻳﺎي ﻓﺮم داروﻳﻲ  ﻣﻲﻓﻴﺰﻳﻜﻮﺷـﻴﻤﻴﺎﻳﻲ آن ارزﻳﺎﺑﻲ ﺧﺼﻮﺻﻴﺎت رﮔﻞ و ﺗﺤﻘﻴﻖ اراﺋﻪ ﻓﺮﻣﻮﻻﺳﻴﻮن ﻗﺮص ﺟﻮﺷﺎن ﺳﺮﺧﺎﻫﺪف اﻳﻦ  ،ﻣﺼﺮف ﺑﺎﺷﺪ. ﻣﻲ ﺪ.ﻋﺒـﻮر داده ﺷ ـ 53، از اﻟﻚ ﺑـﺎ ﻣـﺶ ﺗﻬﻴﻪ و ﭘﺲ از آﺳﻴﺎبزرﺑﻨﺪ  داروﻳﻲ  ﮔﻴﺎه اﻛﻴﻨﺎﺳﻪ از ﺷﺮﻛﺖرﻳﺸﻪ : ﻫﺎ روشﮔﻴـﺎه ﺑـﺮ اﺳـﺎس  ياﺳﺘﺎﻧﺪاردﺳﺎز اﺳﺘﻔﺎده ﮔﺮدﻳﺪ. %08ﺮاﺳﻴﻮن ﮔﺮم ﺑﺎ اﺗﺎﻧﻮل ﮔﻴﺮي ﮔﻴﺎه از روش ﻣﺎﺳ ﺟﻬﺖ ﻋﺼﺎرهاﻧﺠﺎم ﺷـﺪ. ﺳـﭙﺲ ﺗﻌﻴـﻴﻦ ﻧﺴـﺒﺖ ﻣـﻮاد ﻣـﻮرد ﻧﻴـﺎز ﺑـﺮاي  ﺑﺎ روش ﻓﻮﻟﻴﻦ ﺳﻴﻮﻛﺎﻟﺘﻮ ﺗﺮﻛﻴﺒﺎت ﻓﻨﻮﻟﻴﻚﺗﻌﻴﻴﻦ ﻣﻘﺪار ﻜﺮﺑﻨـﺎت ﺑـﻪ ﺗﺮﻛﻴﺒﺎت ﻗﻠﻴﺎﻳﻲ ﻣﺜـﻞ ﺳـﺪﻳﻢ ﺑﻴ ﻴﺪ و ﺟﻮﺷﺶ ﺷﺎﻣﻞ ﺗﺮﻛﻴﺒﺎت اﺳﻴﺪي ﻣﺜﻞ ﺳﻴﺘﺮﻳﻚ اﺳﻴﺪ، ﺗﺎرﺗﺎرﻳﻚ اﺳﻫﺎﻳﻲ  ﻮﻻﺳﻴﻮنﮔﺮاد اﻧﺠﺎم ﺷﺪ. ﭘﺲ از ﺑﺮرﺳﻲ، ﻓﺮﻣ درﺟﻪ ﺳﺎﻧﺘﻲ 501ه از آون در دﻣﺎي روش ﮔﺮاﻧﻮﻻﺳﻴﻮن ﺑﺎ اﺳﺘﻔﺎدﻫﺎي ﻣﻨﺎﺳﺐ اﻧﺘﺨﺎب ﺷﺪﻧﺪ. ﻣﻘﺪار ﻣﻨﺎﺳﺐ از ﻋﺼﺎره ﺳﺮﺧﺎرﮔﻞ ﺑﻪ ﻫﻤﺮاه ﺗﺮﻛﻴﺒﺎت دﻳﮕـﺮ ﻣﺜـﻞ ﻋﺎﻣـﻞ ﺗـﺮ  ﺑﺎ ﻧﺴﺒﺖﻫﺎ ﻣﻮرد ﺑﺮرﺳﻲ ﻗـﺮار ﮔﺮﻓـﺖ. ﭘـﺲ از  ﻓﺮﻣﻮﻻﺳﻴﻮن Hpﺳﭙﺲ ﺟﻮﺷﺶ، ﺣﻼﻟﻴﺖ و  و( اﺿﺎﻓﻪ ﺷﺪ 06)اﺳﭙﻦ  ﻛﻨﻨﺪه ﻫﺎي ﻓﻴﺰﻳﻜﻮﺷﻴﻤﻴﺎﻳﻲ ﺒﻪ ﭘﺮس ﺷﺪه و ﺑﺮرﺳﻲﺳﺘﮕﺎه ﭘﺮس ﻗﺮص ﺗﻚ ﺳﻨﺑﺎ اﺳﺘﻔﺎده از داﻧﺘﺨﺎب ﻓﺮﻣﻮﻻﺳﻴﻮن ﻣﻨﺎﺳﺐ  ﻣﻮردو درﺻﺪ ﻣﺤﺘﻮاي آب  Hp، زﻣﺎن ﺟﻮﺷﺶ، ﻣﺆﺛﺮه، ﻣﻘﺪار ﻣﺎده يﺮﻳﭘﺬ ﺶﻳﻓﺮﺳﺎﺷﺎﻣﻞ ﻧﻮﺳﺎﻧﺎت وزﻧﻲ، ﺳﺨﺘﻲ،   زﻳﺎﺑﻲ ﻗﺮار ﮔﺮﻓﺘﻪ ﺷﺪ.ارﮔﻴـﺎه ﺗﺎم ﻣﻌﺎدل ﮔﺎﻟﻴـﻚ اﺳـﻴﺪ در و ﻣﻘﺪار ﺗﺮﻛﻴﺒﺎت ﻓﻨﻠﻴﻚ وزﻧﻲ/وزﻧﻲ  %02/08 ﮔﻴﺎه درﺻﺪ ﻋﺼﺎره ﮔﻴﺮيﻫﺎ:  ﻪﻳﺎﻓﺘدر آب ﺣـﻞ ﺷـﺪه و  ﻲﺧﻮﺑ ﺑﻪﺟﻮﺷﺎن  ﻫﺎي ﻗﺮص ﻋﺼﺎره ﮔﻴﺎه ﺗﻌﻴﻴﻦ ﮔﺮدﻳﺪ. ﮔﺮم ﻲﻠﻴﻣدر ﺻﺪ  ﮔﺮم ﻲﻠﻴﻣ 5/65ﺑﺮاﺑﺮ در ﻫـﺮ  ﺗﺮﻛﻴﺒﺎت ﻓﻨﻠﻴـﻚ ﻣﻘﺪار ﺛﺎﻧﻴﻪ و  55/66±1/25 ﻫﺎ ﻗﺮصﺟﻮﺷﺶ  ﺑﻪ دﺳﺖ آﻣﺪ. زﻣﺎن 4/48±0/12ﻫﺎ  آن Hp  ﺑﻪ دﺳﺖ آﻣﺪ.ﻛﻴﻠﻮﭘﺎﺳﻜﺎل  4/03 ±0/40         ﻫﺎ ﻗﺮصﻫﻤﭽﻨﻴﻦ ﺳﺨﺘﻲ ﺑﻮد. ﮔﺮم  ﻣﻴﻠﻲ 72/08 ﺟﻮﺷﺎنﻗﺮص ﺎﺑﻲ ﺷﺎﻣﻞ ﻋﺼﺎره ﺳﺮﺧﺎرﮔﻞ، ﺑﺎ ﺗﻮﺟﻪ ﺑﻪ ﻧﺘﺎﻳﺞ ﺑﺮرﺳﻲ ﺧﺼﻮﺻﻴﺎت ﻓﻴﺰﻳﻜﻮﺷﻴﻤﻴﺎﻳﻲ، ﻓﺮﻣﻮﻻﺳﻴﻮن اﻧﺘﺨ: ﮔﻴﺮي ﻧﺘﻴﺠﻪاﻧﺒﻮه ﺗﻮﻟﻴﺪ ﺷﺪه و ﻣـﻮرد  ﺻﻮرت ﺑﻪﺗﻮاﻧﺪ  اﺳﺖ ﻛﻪ ﻣﻲ 06ﻦ ﻜﺮﺑﻨﺎت، ﺳﻴﺘﺮﻳﻚ اﺳﻴﺪ، ﺗﺎرﺗﺎرﻳﻚ اﺳﻴﺪ و اﺳﭙﺳﺪﻳﻢ ﺑﻴ اﺳﺘﻔﺎده ﻗﺮار ﮔﻴﺮد. ﻓﺮﻣﻮﻻﺳﻴﻮن اﻛﻴﻨﺎﺳﻪ، ﺟﻮﺷﺎن، ﻗﺮص :ﻛﻠﻴﺪي ﻛﻠﻤﺎت                  Objective: In traditional medicine, Echinacea (Echinacea purpurea) has been used to prevent and treat a wide range of illnesses such as common colds, cough, bronchitis, pulmonary infections and even chronic diseases caused by immunodeficiency. Due to the advantages of effervescent form of the drug, including undesirable taste, better solubility and ease of use, the aim of this study was to provide the formulation of an effervescent tablet of E. purpurea andevaluation of its physicochemical properties.  Method: The root of plant was obtained from Zarband Pharmaceutical Company and after milling; the sieve was crossed with 35 meshes. To extract the plant, hot maceration method with 80% ethanol was used. Plant standardization was performed based on phenolic content (equivalent to gallic acid). The ratio of materials needed for boiling including acidic compounds such as citric acid, tartaric acid and alkali compounds such as sodium bicarbonate was determined by granulation method using an oven at 105°C. After examination, formulations with proper ratios were selected. The appropriate amount of the E. purpurea extract was added along with other compounds such as wetting agent (span 60), and then boiling, solubility and pH of the formulations were evaluated. After selecting the appropriate formulation using pressed single punch tablet machine and physicochemical investigations including weight fluctuations, hardness, erodibility, the active ingredient content, effervescence time, pH and percentage of water content were evaluated.  Results: The percentage of Echinacea extract was 20.80% (w/w) and the amount of phenolic compounds was 5.56 mg/100 mg dried extract. The effervescent tablets were dissolved in water properly and their pH was 4.84±0.21. The effervescence time of the tablets was 55.66±1.52 seconds and the amount of phenolic content was 27.8 mg in each effervescent tablet. Also the hardness of the tablets was obtained 4.30 ± 0.04 KPa.  Conclusion: According to the appropriate physiochemical characterisitics examination of the selected formulation which was composed of E. purpurea extract, sodium bicarbonate, citric acid, tartaric acid and span 60, it can be produced in large scale.  Keywords: Effervescent tablets, Echinacea, Formulation.   

فرمولاسیون و بررسی خواص فیزیکوشیمیایی قرص جوشان عصاره اتانولی استاندارد شده ریشه گیاه سرخارگل (Echinacea purpurea)

http://eprints.kmu.ac.ir/32063/1/7499.pdf

فرمولاسیون و بررسی خواص فیزیکوشیمیایی قرص جوشان عصاره اتانولی استاندارد شده ریشه گیاه سرخارگل (Echinacea purpurea)

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