Rajabi, Azam

Simorgh Research Repository

    ﻛﺮﻣﺎن ﭘﺰﺷﻜﻲ ﻋﻠﻮم داﻧﺸﮕﺎه  ﺑﻬﺪاﺷﺖ داﻧﺸﻜﺪه  ﺳﻢ ﺷﻨﺎﺳﻲ ﻣﺤﻴﻂ – ﻣﺤﻴﻂ ﺑﻬﺪاﺷﺖ رﺷﺘﻪ ارﺷﺪ ﻛﺎرﺷﻨﺎﺳﻲ ﻣﻘﻄﻊ ﻧﺎﻣﻪ ﭘﺎﻳﺎن  :ﻋﻨﻮان و ﻛﺎدﻣﻴﻢ آرﺳﻨﻴﻚ، ﺳﺮب،) ﺳﻤﻲ ﺳﻨﮕﻴﻦ ﻓﻠﺰات ﺑﺎ ﻣﻮاﺟﻬﻪ ﺳﻼﻣﺘﻲ ﺧﻄﺮ ارزﻳﺎﺑﻲ در ﻣﻮﺟﻮد ﻧﺸﻴﻨﻲ ﺗﻪ ﻗﺎﺑﻞ ذرات  ﺑﻪ ﻣﺮﺑﻮط ﻫﺎي داده ﺗﺤﻠﻴﻞ و ﺗﺠﺰﻳﻪ ﻃﺮﻳﻖ از( ﺟﻴﻮه  ﻛﺮﻣﺎن ﺷﻬﺮ ﺳﺎﻛﻨﻴﻦ ﺧﻮن و ﺗﻨﻔﺴﻲ ﻫﻮاي    اﻋﻈﻢ رﺟﺒﻲ: ﺗﻮﺳﻂ  ﻣﺠﻴﺪ آﻗﺎﺳﻲ دﻛﺘﺮ: راﻫﻨﻤﺎ اﺳﺘﺎد  7931: ﺗﺤﺼﻴﻠﻲ ﺳﺎل    ﻓﻠﺰات ﺳﻨﮕﻴﻦ ﺧﺼﻮﺻﺎ ﺳﺮب، ﻛﺎدﻣﻴﻢ، ﻛﺮوم و آرﺳﻨﻴﻚ ﻋﻨﺎﺻﺮي ﺳﻤﻲ ﻫﺴﺘﻨﺪ و ﻣﻲ ﺗﻮاﻧﻨﺪ ﻋﻮارض ﻣﻘﺪﻣﻪ و اﻫﺪاف: ﺟﺪي ﺑﺮاي ﺳﻼﻣﺘﻲ اﻧﺴﺎن اﻳﺠﺎد ﻧﻤﺎﻳﻨﺪ. ﻫﺪف ﻣﻄﺎﻟﻌﻪ ﻛﻨﻮﻧﻲ ارزﻳﺎﺑﻲ رﻳﺴﻚ ﺳﺮﻃﺎن زاﻳﻲ و ﻏﻴﺮ ﺳﺮﻃﺎن زاﻳﻲ ﻣﻮاﺟﻬﻪ ﺑﺎ  ﺧﻮن در ﻣﻮﺟﻮد ﺳﻨﮕﻴﻦ ﻓﻠﺰات زﻳﺴﺘﻲ ﭘﺎﻳﺶو  ﺮ ﻛﺮﻣﺎنﻓﻠﺰات ﺳﻨﮕﻴﻦ ﻣﻮرد ﻧﻈﺮ در ﮔﺮد و ﻏﺒﺎر ﻣﻮﺟﻮد در ﻫﻮاي ﺷﻬ  ﻣﻲ ﺑﺎﺷﺪ. ﺷﻬﺮ ﺳﺎﻛﻨﻴﻦﭘﮋوﻫﺶ ﺣﺎﺿﺮ ﻳﻚ ﻣﻄﺎﻟﻌﻪ ﺗﻮﺻﻴﻔﻲ ﻣﻘﻄﻌﻲ اﺳﺖ و ﺑﺮاﺳﺎس ﻧﻤﻮﻧﻪ ﺑﺮداري از ﮔﺮد و ﻏﺒﺎر ﻣﻮﺟﻮد در ﻫﻮا ﺑﺎ روش  روش ﻫﺎ:از  ﻧﻤﻮﻧﻪ ﺑﺮدارياﻧﺠﺎم ﮔﺮﻓﺖ. در ﻫﺸﺖ ﻣﻜﺎن ﻧﻤﻮﻧﻪ ﺑﺮداري از ﺧﻮن  و ﻣﻲ ﺑﺎﺷﺪ evissapﻛﻪ ﻳﻚ روش  raj llaf tsudﻣﺤﻞ و  8ﻧﻮﺑﺖ اﻧﺠﺎم ﮔﺮﻓﺖ. ﻧﻤﻮﻧﻪ ﺑﺮداري ﺑﺮ اﺳﺎس روش ﻧﻤﻮﻧﻪ ﮔﻴﺮي ﺗﺼﺎدﻓﻲ در  3روز و در  03ﺑﻪ ﻣﺪت  ﮔﺮد و ﻏﺒﺎرﻧﻤﻮﻧﻪ ﺑﺮداري از ﺧﻮن ﺑﺮ اﺳﺎس روش ﻧﻤﻮﻧﻪ ﮔﻴﺮي ﺗﺼﺎدﻓﻲ در ﻧﻤﻮﻧﻪ اﻧﺠﺎم ﮔﺮﻓﺖ.  42ﻧﻤﻮﻧﻪ ﺟﻤﻌﺎ ﺑﻪ ﺗﻌﺪاد  3از ﻫﺮ ﻣﺤﻞ ﻧﻤﻮﻧﻪ ﻫﺎ ﺑﻌﺪ از آﻣﺎده ﺳﺎزي ﺑﻪ روش ﻫﻀﻢ اﺳﻴﺪي  ﻧﻤﻮﻧﻪ اﻧﺠﺎم ﮔﺮﻓﺖ. 08ﻪ ﺗﻌﺪاد ﻧﻔﺮ ﺟﻤﻌﺎ ﺑ 01ﻣﺤﻞ و از ﻫﺮ ﻣﺤﻞ  8ﺟﻬﺖ اﻧﺪازه ﮔﻴﺮي ﻓﻠﺰات ﺳﻨﮕﻴﻦ ﻣﻮرد ﻧﻈﺮ ﻣﻮرد ﺑﺮرﺳﻲ ﻗﺮار ﮔﺮﻓﺘﻨﺪ. ﻏﻠﻈﺖ ﻣﺤﺎﺳﺒﻪ  SEO‐PCIﺑﺎ اﺳﺘﻔﺎده از دﺳﺘﮕﺎه ﺴﻚ ﺳﻼﻣﺘﻲ )ﺳﺮﻃﺎن ﺷﺪه ﻋﻨﺎﺻﺮ ﻣﻮرد ﻧﻈﺮ ﺑﺎ اﺳﺘﻔﺎده از ﻓﺮﻣﻮل ﻫﺎي اﺧﺘﺼﺎﺻﻲ ﺟﻬﺖ ﻣﺤﺎﺳﺒﻪ رﻳﺴﻚ اﻛﻮﻟﻮژﻳﻜﻲ و رﻳ  زاﻳﻲ و ﻏﻴﺮ ﺳﺮﻃﺎن زاﻳﻲ( ﺑﻪ ﻛﺎر ﮔﺮﻓﺘﻪ ﺷﺪ.ﻧﺘﺎﻳﺞ ﻣﻄﺎﻟﻌﻪ ﺣﺎﺿﺮ وﺟﻮد ﻏﻠﻈﺘﻲ از ﻓﻠﺰات ﺳﻨﮕﻴﻦ ﺳﻤﻲ ﺳﺮب، ﻛﺎدﻣﻴﻢ، آرﺳﻨﻴﻚ و ﻛﺮوم در ﮔﺮد و ﻏﺒﺎر ﻣﻮﺟﻮد ﻳﺎﻓﺘﻪ ﻫﺎ:  اﻓﺮاد ﺧﻮن در ﻋﻨﺎﺻﺮ ﻏﻠﻈﺖ ﺑﻴﺸﺘﺮﻳﻦ داد ﻧﺸﺎن ﻧﺘﺎﻳﺞﻫﻤﭽﻨﻴﻦ  را ﺗﺎﻳﻴﺪ ﻧﻤﻮد. و ﺧﻮن ﺳﺎﻛﻨﻴﻦ ﺷﻬﺮ در ﻫﻮاي ﺷﻬﺮ ﻛﺮﻣﺎن ﻧﺸﺎن ﺳﺎﻛﻨﻴﻦ، ﺧﻮن در ﻛﺮوم و آرﺳﻨﻴﻚ ﻛﺎدﻣﻴﻢ، ﺳﺮب، ﺳﻤﻲ ﺳﻨﮕﻴﻦ ﻓﻠﺰات ﻏﻠﻈﺖ. ﺑﺎﺷﺪ ﻣﻲ آزادي و ﻣﺸﺘﺎق ﻣﻨﺎﻃﻖ  .ﻛﻨﻨﺪ ﻣﻲ ﭘﻴﺪا ﺗﻤﺎس ﻫﻮا در ﻣﻮﺟﻮد ﻏﺒﺎر و ﮔﺮد ﺟﻤﻠﻪ از ﻣﺨﺘﻠﻔﻲ ﻃﺮق از دﻫﺪ ﻣﻲو ﭘﺘﺎﻧﺴﻴﻞ رﻳﺴﻚ اﻛﻮﻟﻮژﻳﻜﻲ ﻧﺘﺎﻳﺞ ﻧﺸﺎن داد ﺑﻴﺸﺘﺮﻳﻦ ﻏﻠﻈﺖ ﻋﻨﺎﺻﺮ در ﻣﻨﺎﻃﻖ ﻣﺸﺘﺎق و آزادي ﻣﻲ ﺑﺎﺷﺪ  ﻧﺘﻴﺠﻪ ﮔﻴﺮي:ﻣﺠﻤﻮع ﻋﻨﺎﺻﺮ ﻛﻢ ﻣﻲ ﺑﺎﺷﺪ. رﻳﺴﻚ ﻏﻴﺮﺳﺮﻃﺎن زاﻳﻲ ﻧﻴﺰ ﻳﺎﻓﺖ ﻧﺸﺪ. وﺟﻮد ﻓﻠﺰات ﺳﻨﮕﻴﻦ در ﮔﺮد و ﻏﺒﺎر ﻣﻮﺟﻮد در ﻫﻮاي وﺟﻮد اﻳﻦ ﻋﻨﺎﺻﺮ در  .ﺗﻨﻔﺴﻲ ﺷﻬﺮ ﻛﺮﻣﺎن ﻣﻲ ﺗﻮاﻧﺪ ﻋﻮارﺿﻲ را ﺑﺮاي ﺳﺎﻛﻨﻴﻦ ﻣﺤﻞ ﺧﺼﻮﺻﺎ ﻛﻮدﻛﺎن ﺑﻪ ﻫﻤﺮاه داﺷﺘﻪ ﺑﺎﺷﺪ  ﺳﻼﻣﺘﻲ آن ﻫﺎ ﺗﺎﺛﻴﺮ ﮔﺬاﺷﺘﻪ و ﻋﻮارﺿﻲ را اﻳﺠﺎد ﻛﻨﺪ.ﺧﻮن اﻳﻦ اﻓﺮاد ﻣﻲ ﺗﻮاﻧﺪ در  : هژاو ﺪﻴﻠﻛﻲﺑﺎﻳزرا تاﺰﻠﻓ ،ﺮﻄﺧ ﻦﻴﮕﻨﺳ نﺎﻣﺮﻛ ،نﻮﺧ ، ﻲﻨﻴﺸﻧ ﻪﺗ ﻞﺑﺎﻗ تارذ ،ﻲﻤﺳ     Abstract Introduction: Heavy metals, particularly lead, cadmium, chromium, arsenic, and mercury, are toxic elements and can cause serious complications for human health. The aim of the present study is carcinogenic and non-carcinogenic risk assessment of exposure to heavy metals found in dust in the air of Kerman, Iran.  Methods: The present study is a descriptive cross-sectional study and is conducted based on dust sampling using dust fall jar, which is a passive method. The sampling was conducted 3 times during 30 days. The sampling was performed in 8 locations selected by random sampling method yielding a total of 24 samples (3 samples per location). The samples were examined after being prepared by acid digestion using ICP-OES to measure the heavy metals. The calculated concentration of the elements was applied using specific formulas to calculate the ecological and health risk (carcinogenic and non-carcinogenic).  Results: The results of the present study confirmed a concentration of toxic heavy metals, including lead, cadmium, arsenic and chromium, found in dust in the air of Kerman. Conclusion: The results showed that the highest concentration of elements are in the Moshtagh and Azadi districts, and the potential of ecological risk is low for all elements. No non-carcinogenic risk was found. The presence of heavy metals found in dust in the air of Kerman can cause complications for residents, especially children. Keywords: risk Assessment, toxic heavy metals, Deposited particles, blood, Kerman         Kerman University of Medical Sciences faculty of Health Master of Science Degree in Environmental Health - Environmental ToxicologyTitle: Health Risk Assessment of Toxic Heavy Metals (Pb, As, Hg, Cd) Exposure Through Analysis of Deposited particles and Inhabitants Blood in Kerman City, Iran   By: Azam Rajabi Supervisor: Dr. Majid Aghasi Academic Year: 2019    

ارزیابی خطر سلامتی مواجهه با فلزات سنگین سمی (سرب، آرسنیک، کادمیم و جیوه) از طریق تجزیه و تحلیل داده های مربوط به  ذرات قابل ته نشینی موجود در هوای تنفسی و خون ساکنین شهر کرمان

http://eprints.kmu.ac.ir/31876/1/7385.pdf

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