Buchanan, Vanessa

D'Souza, Vijay K.

Dhanasiri, Sujith

Ramasamy, Karthik

Robinson, Suzanne

Thom, Howard

Weisel, Katja

English

Established treatments for transplant-ineligible (TNE) patients with newly diagnosed multiple myeloma (NDMM) include melphalan and prednisone (MP) combined with either bortezomib (VMP) or thalidomide (MPT), or lenalidomide plus low-dose dexamethasone (Rd). New treatments for TNE NDMM include Rd plus bortezomib (RVd) and daratumumab plus VMP (VMP + D), daratumumab plus lenalidomide and dexamethasone (D + Rd). Relative efficacy of these treatments was compared using a network meta-analysis. Eight trials identified by a systematic literature review were included in the primary analysis; hazard ratios (HRs) for overall survival (OS) and progression-free survival (PFS) were used. Rd was superior to other MP-based regimens for OS and PFS. There was strong evidence that, compared with Rd, both D + Rd and RVd improved PFS (HR 0.57; 95% credible interval (CrI) 0.43, 0.73 and HR 0.72; 95% CrI 0.56, 0.91, respectively). However, there was strong evidence only for RVd in respect to OS (HR 0.72; 95% CrI 0.52, 0.96)

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Relative efficacy of treatment options in transplant-ineligible newly diagnosed multiple myeloma:results from a systematic literature review and network meta-analysis

https://research-information.bris.ac.uk/ws/files/218244533/Relative_efficacy_of_treatment_options_in_transplant_ineligible_newly_diagnosed_multiple_myeloma_results_from_a_systematic_literature_review_and.pdf

Relative efficacy of treatment options in transplant-ineligible newly diagnosed multiple myeloma:results from a systematic literature review and network meta-analysis

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