dashti, fariba

khadem haghighian, hosein

Qazvin University of Medical Sciences Repository

  قزوین دانشگاه علوم پزشکی و خدمات بهداشتی درمانی دانشکده بهداشت رشته علوم بهداشتی در تغذیه در ارشد كارشناسی درجه اخذ جهت نامه پایان  عنوانبر میزان  ایرانی و موضعی بره مومخوراكی  مکملیاریتاثیر  بررسیسطوح ظرفیت آنتی اكسیدانی تام سرم و مالون دی آلدئید سرم در  بیماران مبتلا به زخم پای دیابتی  راهنما استاد حسین خادم حقیقیاندكتر  مشاور داتیاس سیما هاشمی پوردكتر  شنگار فریبا دشتی13تیرماه  چکیده : زمینه و هدفها:  مواد و روش : ها یافته   Abstract Background: Diabetic foot ulcer is the most important microvascular complication of diabetes mellitus. Several previous studies have demonstrated that foot ulcer in diabetic patients resulted in oxidative stress condition. Propolis, a resinous honeybee product, has shown different therapeutic effects because of various constituents such as flavonoids, terpenes, phenolic acids and abundant vitamins and minerals. This study aimed to evaluate the effects of propolis in reducing oxidative stress in patients with diabetic foot ulcers. Materials and Methods: In this randomized clinical trial, eighty diabetic patients with foot ulcer (Wagner grades 2 and 3) were randomly divided into 4 groups. The first group received 3 capsules containing 500 mg propolis, the second group used topical propolis ointment (1.5 g daily), the third group received propolis capsules (1500 mg daily) and ointment (1.5 g/day), and the fourth group received conventional therapies alone. The process of ulcer healing was observed during 4 weeks and compared between the four groups regarding the Total antioxidant capacity (TAC) and Malondialdehyde (MDA) serum levels. The data were analyzed by SPSS version 20 and Paired T-test and ANOVA test were used to compare changes into and between groups.  Results: Four weeks after the intervention, the mean TAC considerably increased in group 1 from  1.01±0.2 to 1.26±0.13 µmol/l (p=0.038), from 0.98±0.18 to 1.33±0.23 µmol/l (p=0.029) in group 2, and from 1.01±0.13 to 1.29±0.2 µmol/l (p=0.034) in group 3. This difference was not significant in group 4 (p=0.1). A significant reduction was observed in the mean of serum MDA in group 2 and group 3 (P=0.045, p=0.033 respectively). However MDA changes were not significant in group 1 and in group 4. Conclusion: Based on this study, the daily intake of 1500 mg of propolis capsule and 1.5 g propolis oinment for 4 weeks could reduce MDA and increased TAC without any significant adverse effects. Therefore, the use of propolis may be extended to the clinical setting and prove an effective promoter of wound healing in patients with diabetes. Keywords: Diabetic foot ulcer; Propolis; Stress oxidative; Total antioxidant capacity; Malon dialdehyde                 Qazvin university of Medical Sciences Faculty of Health A Thesis Presented for the degree of Master of sciences ( M.Sc.) in Health Sciences in Nutrition  Title: The effect of Iranian propolis supplementary as orally and topical on serum Total antioxidant capacity and Malondyaldehyde in diabetic foot   ulcer patients  Supervisor: Dr.Hosein Khadem Haghighian (Ph.D) Adviser: Dr.Sima Hashemipour  By: Fariba Dashti  August -2019 

بررسی تاثیر مکملیاری خوراکی و موضعی بره موم ایرانی بر میزان سطوح ظرفیت آنتی اکسیدانی تام سرم و مالون دی آلدئید سرم در بیماران مبتلا به زخم پای دیابتی

بررسی تاثیر مکمل یاری خوراکی و موضعی با بره موم بر میزان سطوح ظرفیت آنتی اکسیدانی تام و مالون دی آلدئید سرم در بیماران مبتلا به زخم پای دیابتی (فایل دفاع نهایی)

http://eprints.qums.ac.ir/9108/1/Abstract%20dashti.pdf

بررسی تاثیر مکملیاری خوراکی و موضعی بره موم ایرانی بر میزان سطوح ظرفیت آنتی اکسیدانی تام سرم و مالون دی آلدئید سرم در بیماران مبتلا به زخم پای دیابتی

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Qazvin University of Medical Sciences Repository

Qazvin University of Medical Sciences Repository