thesis
Btk at the Pre-B Cell Receptor Checkpoint
- Publication date
- 19 May 2004
- Publisher
- Signalling from the BCR or its immature form, the pre-BCR, was shown to be crucial for B
cell development. Gene-targeted mice have defined differential roles of components of the
(pre-) BCR complex or its downstream signalling pathways. One of the proteins involved in
(pre-) BCR signalling is the cytoplasmic protein Bruton’s tyrosine kinase (Btk). Mice deficient
in Btk have B cell differentiation defects resulting in an X-linked immunodefi ciency (xid)
phenotype. The xid phenotype is characterized by a reduction in the number of peripheral
B cells and the residual B cell have an immature phenotype, indicating that the lack of Btk
causes a block in peripheral B cell d