Oral presentation at the West African College of Physicians 44th & 45th Annual General and Scientific Meetin

Genekah, Monica

Jawara, Maryama

Kampmann, Beate

Kandeh, Sheriff

Nkereuwem, Esin

Togun, Toyin

Tunkara, Abdoulie

LSHTM Research Online

Abstract 43REDUCED HEALTH-RELATED QUALITY OF LIFE AFTER TUBERCULOSIS TREATMENT IN GAMBIAN CHILDRENType: AS: Abstract SubmissionTopic: AS02 Age-related healthcare / 2.1 Maternal, newborn and child healthAuthors: E. Nkereuwem1,2, M. Genekah1, M. Jawara1, S. Kandeh1, A. Tunkara1, B. Kampmann1,3, T. Togun1,2; 1MRC Unit TheGambia at LSHTM, Vaccines and Immunity Theme, Fajara, Gambia, 2London School of Hygiene and TropicalMedicine, TB Centre and Faculty of Infectious and Tropical Diseases, London, United Kingdom, 3London School ofHygiene and Tropical Medicine, The Vaccine Centre, London, United KingdomBackgroundChronic physical and psychological consequences such as reduced health-related quality of life (HRQoL) followingtreatment of pulmonary tuberculosis (PTB) are increasingly recognised as debilitating critical outcomes in adults. However,data on the prevalence and pattern of this complication are sparse among children who suffered from PTB. We presentHRQoL data of children at least six months after completing PTB treatment in The Gambia. MethodsThis was a cross-sectional comparative study. We used the generic Paediatric Quality of Life Inventory 4.0 (PedsQL™ 4.0)instrument to measure the HRQoL among children (aged 5 to 15 years) who were diagnosed with PTB between 2014 and2019 and had completed anti-tuberculous treatment at least six months before enrolment. We also enrolled a comparisongroup of healthy children who lived in the same compound as the post-TB cases but with no history of TB disease. HRQoLwas measured in six scales: physical health, emotional functioning, social functioning, school functioning, psychosocialhealth (combined score of the emotional, social, and school functioning subscales) and a total scale. The responses werecollected from the child and the parent independently. ResultsWe enrolled 68 post-TB cases (47% females) and 91 healthy controls (37% females). The post-TB cases reportedsignificantly lower mean % HRQoL scores (69·4 ± 23·2) on the self-reported physical functioning scale of the PedsQL™compared to the healthy children (77·5 ± 20·3), p = 0·03. Similarly, the post-TB cases had significantly lower mean % scorescompared to the healthy children in five out of six of the parent-reported PedsQL™ scales (see figure).hrqol abstract image.jpg enlarge ConclusionsPost-TB cases had significantly lower HRQoL scores compared to healthy children. This study highlights the need forlongitudinal assessment of physical and psychosocial health after PTB treatment completion to better understand theevolution and risk factors of poor quality of life outcomes among these children. Print

Reduced health-related quality of life after tuberculosis treatment in Gambian children

https://researchonline.lshtm.ac.uk/id/eprint/4665562/1/Nkereuwem_etal_2022-Reduced-health-related-quality-of-life.pdf

Reduced health-related quality of life after tuberculosis treatment in Gambian children

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