In order to sustain nomml function, the heart is dependent on an adequate delivery of oxygen
and substrates to the heart to m

Jonge, R. (Robert) de

In order to sustain nomml function, the heart is dependent on an adequate delivery of oxygen
and substrates to the heart to meet the energy demands of the contracting muscle. Myocardial ischemia
can be defined as "an imbalance between the amount of oxygen and substrates supplied to the heart and
the amount needed to perfoml normal function". Ischemic heart disease is one of the major causes
of death in the world including developing countries. Depending on factors like the amount of
collateral flow, myocardial necrosis develops after 10-20 min of ischemia. 'Ischemic preconditioning',
one of the 'New Ischemic Syndromes'  refers to the mechanism that short periods of (nonlethal)
ischemia and reperfusion protect the heart from injury during a subsequent prolonged period of ischemia.
It was first described in 1986 by Murry et al. In dog hearts, these investigators showed
that infarct size resulting from 40·min coronary artery occlusion was reduced by 75% when ischemia
was preceded by four cycles of 5 min coronary artery occlusion and reperfusion

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Adenosine, carbohydrates, and ischemic preconditioning

http://repub.eur.nl/pub/20007/990908_JONGE,%20Robert%20de.pdf

Adenosine, carbohydrates, and ischemic preconditioning

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