Aneuploidy screening of human IVF embryos: Cytogenetic aspects and clinical implications

Abstract

The introduction of this thesis provides the reader with the necessary background information to understand the rationale behind the studies conducted. It starts with the observation that human incidence of chromosomal abnormalities in oocytes and embryos. Furthermore, an explanation is given why selection of the embryo with the best implantation potential for transfer to the uterine cavity is becoming increasingly important for IVF treatment cycles. Mechanisms of aneuploidy formation in oocytes and embryos are discussed and the phenomenon of chromosomal mosaicism in embryos is introduced. The possibilities and problems when using preimplantation genetic screening are described. Subsequently, an outline of approaches used for ovarian(hyper) quality and chromosome competence of resulting embryos. The chapter then proceeds with stating the objectives and outline of the thesis