research
Plasticity in eye movement control
- Publication date
- 26 October 2005
- Publisher
- The cerebellum plays an important role in the recalibration and adaptive adjustment of
movements, as well as learning new motor skills and motor related associations. In this thesis,
we investigated the mechanisms underlying cerebellar motor learning. To obtain a better
understanding, in how the cerebellum processes and stores information, we used specific
perturbations that affected the information processing of the cerebellum. Signal transduction
pathways were affected that were considered important for cerebellar motor learning by using
genetic tools (transgenic mice) and the application of antibodies.
Alterations in cerebellar
motor learning were studied by monitoring the oculomotor system of these transgenic and
treated mice.