This article analyzes the peculiarities of the cultural diplomacy activity of the Republic of Moldova in the context of the realization of the European path. The authors investigate cultural diplomacy as a distinct sphere within the foreign policy of states, with specialized bodies and autonomous means. They set the strategic objectives of cultural diplomacy, distinguishing the tasks of cultural diplomacy. It analyzes the peculiarities of the activity of cultural diplomacy of the European Union and of the Republic of Moldova, as well as the general objectives and directions for developing the cultural policy of the Republic of Moldova. The main instruments of cooperation in the European area are bilateral and multilateral agreements and cultural collaboration programs with different countries. The practices of Moldovan cultural diplomacy in the European space are based on the fundamental objective, that of European integration, which has become the major force of political and social cohesion. The image and interests of the Republic of Moldova must be realized through proper cultural diplomacy and appropriate measures