Vulvar Intraepithelial Neoplasia: New concepts and strategy

Abstract

Vulvar intraepithelial neoplasia (VIN) is a rare condition which can develop into an invasive carcinoma. This skin-disease affects mainly young women, and causes many severe and long-lasting symptoms such as pruritus, vulvodynia and psychosexual dysfunction. Over 80% of VIN-affected women present with multifocal vulvar disease, and often neoplastic changes can be found in the entire lower genital tract. Clinically, it is important to distinguish unifocal from multifocal lesions, since unifocal VIN tends to progress to invasive carcinoma ten times more often than multifocal VIN doe