Monocytes, Dendritic Cells, Macrophages, T cells and Head and Neck Cancer : the effect of a thymic hormone preparation in restoring defective immune functions

Abstract

It is generally accepted that cell mediated immunity (CMI) has more importance in the control of cancer than the antibody-mediated immune response. The cell mediated immune response is the basis of the so-called natural host resistance to cancer, which is also referred to as "immunosurveillance". Although the concept of immunosurveillance has been much debated over the past decades, there is now no doubt that suppression of the immune function increases the incidence of a few types of cancer. Also, spontaneous regression has been observed for some tumors, including melanoma, renal cell carcinoma, and lymphoma, and evidence for a role of immunosurveilance is well supported in these tumors. The role of a cell mediated immunosurveilance in patients with a head and neck squamous cell carcinoma (HNSCC) is less clear. Immunosuppressed patients do not develop head and neck cancer more frequently and spontanous regression is at most anecdotal. Despite this, defects of the CMI in HNSCC patients have extensively been documented. One of the first tests to reflect the status of the CMI which was found abnormal in HNSCC patients, was delayed type hypersensitivity (dth) as measured by skin reactions to ONCB- dinitrochlorobenzene). Ninetyfive percent of the normal adult popUlation react with a dth reaction towards skin-applied ONCB, however such a positive reaction is often absent in HNSCC patients. These observations have not led to a present clinical use of ONCB