thesis
Regulation and modulation of the plasma fibrinogen level
- Publication date
- 1 January 1995
- Publisher
- Fibrinogen is a soluble plasma glycoprotein that, under normal circumstances, is
present in human plasma at a concentration of 2-4 mg/ml (6-12 I'M). The plasma
half-life is 3-4 days in humans and about 10-25 % of the total body fibrinogen is
extravascularl. Fibrinogen is composed of two sets of three polypeptide chains (AOI,
86 . and 'Y) that are interconnected by disulphide bridges . The
aminoterminal segments of all six chains form a central domain from which the AOI
and 86 chains protrude. These aminotermini are the target of thrombin and small
peptides (FPA and FP8) can be cleaved off.