Ultrastructural basis of acute renal allograft rejection

Abstract

An attempt was made: I. to demonstrate the evolution and the time of onset of the ultrastructural morphological changes in the renal parenchyma and blood vessels, as well as the ultrastructural feature of the interstitial cellular infiltration in acute rejection of kidney allografts; 2. to acquire more information about the nature of the rejection processes by studying the sequential development of the ultrastructural lesions in renal allotransplants; and 3. to analyse the effect of various immunosuppressive agents on the fine morphology of acute renal allograft rejection and the extent to which the various features of the rejection process are affected by the immunosuppressive treatment