thesis
Myocardial purine metabolism : aspects of myocardial ATP metabolism and pharmacological intervention
- Publication date
- 4 April 1984
- Publisher
- The heart is obliged to contract continuously. This
implicates for a human with an average heart rate of 70 beats
per minute in about 70 years more than 2.5 billions of
contractions. For this contraction ATP is needed as the main
substrate. As a consequence continuous ATP production by the
heart is obligatory. This ATP is mainly produced by the
oxygen-dependent oxidative phosphorylation. Disturbances of the
oxygen delivery, such as that induced by partial occlusion of
one or more coronary arteries can lead to a distortion of the
balance between ATP production and consumption. As a res11lt,
ATP is dephosphorylated, and subsequently the products
adenosine, inosine, hypoxanthine, xanthine and uric acid pass
the cellular membrane and appear in the coronary effluent.
Because of the importance of adequate ~TP levels for the heart,
the following 4 main ::.\'Venues have been investigated in this
study, which forms the substance of my thesis.