slides
T lymphocytes and cytokines in graft-versus-host disease : a study in mice with emphasis on prevention and treatment.
- Publication date
- 16 December 1992
- Publisher
- This thesis describes the results of experiments aimed to improve the insight into
this complex disease using a murine model. Based on previous work from our
laboratory we investigated the possibilities to prevent GVHD in a specific manner,
namely by pretreatment of prospective donors with a recipient-specific blood transfusion.
Furthermore, we assessed the role of (subsets of) T lymphocytes and of cytokines in
GVHD. Cytokines are factors that can be produced a.o. by T cells and play a central
role in immune and inflammatory reactions. Recent data from the literature indicate
that cytokines might be involved in the development of GVHD. We studied the
therapeutic effect of in vivo administration of anti-T cell (subset), anti-cytokine and
anti-cytokine receptor monoclonal antibodies (mAb) on GVHD