Heterogeneity in acute myeloid leukemia : basic and diagnostic studies

Abstract

The heterogeneity of AML is subject of this thesis. The purpose of this study was to characterize the different subpopulations which can be found in the various types of AML at diagnosis and during follow-up. For this purpose we especially used extensive immunological marker analysis. In close collaboration with clinical scientists and laboratory scientists our results were correlated with other features of these patients, especially clinical characteristics and cytogenetics. Both the clinical significance and some basic aspects of specific immunophenotypes in AML patients were determine