research
Chromatin dynamics and the regulation of B-glohin gene expression
- Publication date
- 10 June 1998
- Publisher
- The human B-globin locus is frequently used as a model system to study mechanisms
controlling tissue-specific and developmentally regulated gene expression. Much of the recent
progress in understanding the regulation of B-globin gene expression has come from a better
knowledge of the process of transcription. Proper transcriptional regulation of the human B-globin
genes occurs, at least in part, through specific interactions of regulatory traus-acting
proteins to defined cis-regulatory sequences that include promoters, enhancers, silencers, and
elements of the locus control region.