Dynamic regulation of GATA transcription factors in hematopoiesis

Abstract

The hematopoietic system is composed of a variety of cells, whose activity is essential for the normal functioning of an organism. Erythrocytes, or red blood cells, transport oxygen and carbon dioxide throughout the body, platelets are essential for coagulation and white blood cells (lymphocytes, granulocytes and macrophages) are responsible for the protection of the organism against pathogens. All these different cells originate from a single cell type, the hematopoietic stem cell (HSC), through a process denominated hematopoiesis. To understand how the HSC can originate so many different cell type has been the aim of many scientists over the years. Advances in molecular biology tools allowed the gathering of vast amounts of information about the hematopoietic system and the process of hematopoiesis. However, many questions remain without answers. The HSC gives rise to the different hematopoetic cell lineages via a series of steps. HSCs are rare cells that have the capacity to duplicate themselves (self-renewal) as well as to give rise to all the different hematopoietic cell types (pluripotency). The descendants of the HSC are still able to give rise to all hematopoietic lineages but they lose the ability to self-renew. These cells will further differentiate into other cells that can give rise to an increasingly restricted number of hematopoietic lineages until they reach a stage were they can only differentiate into a single lineage. Such process is called lineage-commitment and its accuracy is essential for the normal function of the hematopoietic system. How this lineage commitment occurs is as yet not clear. It is known that it is dependent on environmental cues as